Stefano Sturaro, who joined Genoa on loan from Juventus in January before the deal was made permanent, put the home side in front in the second half before fellow substitute Goran Pandev secured the shock result with 10 minutes remaining.
Juventus moved to strengthen their midfield by signing Germany international and World Cup winner Sami Khedira from Real Madrid on a free transfer, the Italian champions said.
- 'We will have to play with a lot of intelligence' - 'We will be able to see a fantastic footballer on the pitch'
'I cannot wait to play at Old Trafford in front of a full stadium and see all the fans again.'
German publication Der Spiegel reported in March that the club's Abu Dhabi owners inflated sponsorship agreements to comply with FFP requirements.
Atletico Madrid coach Diego Simeone is renowned for his wild touchline antics but a shrewd tactical move with a triple substitution swung Wednesday's Champions League game against Juventus firmly his side's way.
Morata to stay on loan at Juventus for another season
Barcelona winger Raphinha secured a 1-0 win in LaLiga for the second straight week this time at Athletic Bilbao as his side tightened their grip on top spot.
But if the five-times World Player of the Year is feeling frustrated by his mini-drought -- and his reactions on the pitch suggest he is -- his worries pale in comparison to Dybala's unhappy start to the season.
Dani Alves appeared to have won the game for Juventus when he headed them in front in the 83rd minute but Remo Freuler pounced to equalise six minutes later as he punished some sloppy defending.
AS Monaco, beaten 2-0 at home in the first leg of their Champions League semi-final against Juventus, will have to make history in Tuesday's return if they are to end Ligue 1's long absence from the final.
Mbappe, 18, has scored 18 goals in his last 18 competitive games, including three in the 6-3 aggregate win over Borussia Dortmund in the last eight.
Images from the football matches played on Tuesday.
Juventus spent about 12 million euros ($13.42 million) to sign Carlos Tevez, a fraction of what Real Madrid paid for Gareth Bale and Cristiano Ronaldo, yet it was the Argentine who called the shots in their Champions League clash on Tuesday.
Juventus look set to wrap up their fourth successive Serie A title in the next seven days although the crowd violence which marred Sunday's 2-1 defeat at Torino could take the shine of their celebrations.
Leaders Barcelona played out a second straight 0-0 draw in LaLiga after mid-table Getafe battled for a home point in a hard-fought game on Sunday.
Champions Real Madrid earned a 2-0 win in a feisty LaLiga encounter at Athletic Bilbao on Sunday to ensure they stayed in the hunt for the LaLiga title with leaders Barcelona.
Second-placed Sevilla were held to a 1-1 draw by Barcelona, while Juventus registered a routine 2-0 win over struggling Cagliari.
Bayern Munich are confident they have overcome a mini-slump just in time for their Champions League round of 16 second leg against Juventus on Wednesday as they chase a treble of titles this season.
Sevilla will attempt to draw Bayern Munich out of their comfort zone and take the game to the Germans,
A summary of sports events and sports persons, who made news on Thursday.
Serie A leaders Juventus scored twice in the last five minutes to win 3-2 at Inter Milan, who had earlier come from behind to lead despite playing with 10 men in an extraordinary match on Saturday.
A round-up of Sunday's matches in LaLiga, Ligue 1 and Serie A
'Betrayed by Ronaldo'
In other ties, Serie A champions Juventus face Europa League winners Atletico Madrid and Barcelona take on Olympique Lyonnais.
Jose Mourinho was delighted that Manchester United were on the brink of signing France midfielder Paul Pogba from Serie A champions Juventus, the Portuguese coach said on Sunday.
It has been a long time coming but Spain look as if they may finally have solved their number nine problems following Alvaro Morata's two goals in the 3-0 win over Turkey.
Barcelona are on the verge of Champions League elimination after being thrashed 3-0 by Juventus in Turin on Tuesday, and few believe lightning can strike twice.
Nineteen-year-old forward Domenico Berardi scored four quickfire goals to give Sassuolo a 4-3 win over AC Milan on Sunday after they overturned an early two-goal deficit against the seven-times European champions.
Champions Juventus returned to the top of Serie A with a 4-0 home rout of Cagliari on Wednesday, while former leaders Napoli dropped to second after being held to a goalless draw at Genoa.
Borussia Dortmund beat Hertha Berlin 3-2 on penalties to reach the German Cup quarter-finals on Wednesday after the match finished 1-1 after extra time.
Juventus midfielder Arturo Vidal smashed home a second-half penalty to earn a 1-0 win at home to Monaco in an absorbing Champions League quarter-final first leg on Tuesday, leaving the tie on a knife-edge.
Juventus continued their charge towards a fourth successive Serie A title as they predictably swept aside AC Milan 3-1 on Saturday to complete a league double over their old rivals.
Napoli suffered their first defeat of the season on Sunday when they lost 1-0 at lowly Atalanta while Serie A leaders Juventus surged on with a 3-0 win at Empoli, helped by a Gonzalo Higuain brace.
Goals by Andrea Barzagli and Mario Lemina propelled Juventus to a 2-0 win at Atalanta Bergamo on Sunday and allowed them to restore their three-point advantage at the top of Serie A.
Juventus won 2-0 at Lazio on Friday to extend their winning run in Serie A to five matches thanks to an early own goal from Santiago Gentiletti and a glorious Paulo Dybala effort.
Sulley Muntari salvaged a point for AC Milan with a second-half equaliser in a 2-2 draw at the San Siro on Monday that saw visiting AS Roma slip five points behind Serie A leaders Juventus.
Juventus will be hoping to make it 11 victories out of 11 against French teams in knockout ties when they face AS Monaco in the second leg of their Champions League quarter-final on Wednesday.
'I would have liked to have scored against another team but that's life'
Seydou Keita cancelled out a superb Carlos Tevez free kick as second-placed AS Roma fought back with 10 men for a fiery 1-1 draw at home to leaders Juventus who stayed on course for a fourth successive Serie A title on Monday.